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Description

Braun, Markus, et al

Dysregulated type I Interferon and inflammatory monocyte-macrophage responses cause Lethal Pneumonia in SARS-CoV-Infected mice

PKC activation induces phosphorylation of the ADAM17 (ADAM Metallopeptidase Domain 17) tail and, subsequently, the phosphorylated ADAM17 tail enhances ACE2 shedding, assists with viral entry and tissue injury [45, 46]